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Article

KRASG12D mutation promotes pancreatic tumorigenesis by suppressing sirtuin three via the guanine nucleotide exchange factor RCC1.

The Journal of biological chemistry - 1 Feb 2026

Mai Taoyi, Wang Mengwen, Qiu Ya, Lu Wenhua, Wu Hongyu, Chen Shuna, Chiao Paul J, Huang Peng

Abstract excerpt

KRASG12D mutation is a prevalent gain-of-function mutation that drives pancreatic cancer tumorigenesis, but the underlying mechanisms that promote KRAS-induced cell proliferation and tumor formation remain elusive. To uncover the molecular pathways that facilitate KRASG12D-driven malignant transformation, we measured the transcriptomic alterations at various time points after induction of KRASG12D expression in...

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Topics

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Share to Carcinogenesis
Share to Gene Expression Regulation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Guanine Nucleotide Exchange Factors

Share to Mice, Nude

Share to Mutation, Missense

Share to Pancreatic Neoplasms

Share to Proto-Oncogene Proteins p21(ras)

Share to Sirtuin 3

Source

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Identifiers

PMID: 41391757
DOI: 10.1016/j.jbc.2025.111057
PMCID: PMC12804135

Genes

SIRT3
RCC1
KRAS
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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