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Article

Elevated expression of nuclear receptor-binding SET domain 3 promotes pancreatic cancer cell growth.

Cell death & disease - 6 Oct 2021

Sun Yihui, Xie Jiaming, Cai Shang, Wang Qian, Feng Zhenyu, Li Yecheng, Lu Jing-Jing, Chen Wei, Ye Zhenyu

Abstract excerpt

The nuclear receptor-binding SET domain 3 (NSD3) catalyzes methylation of histone H3 at lysine 36 (H3K36), and promotes malignant transformation and progression of human cancer. Its expression, potential functions and underlying mechanisms in pancreatic cancer are studied. Bioinformatics studies and results from local human tissues show that NSD3 is upregulated in human pancreatic cancer tissues, which is...

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Identifiers

PMID: 34615858
DOI: 10.1038/s41419-021-04205-6
PMCID: PMC8494902

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