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Article

Role of simple descriptors and applicability domain in predicting change in protein thermostability.

PloS one - 1 Jan 2018

McGuinness Kenneth N, Pan Weilan, Sheridan Robert P, Murphy Grant, Crespo Alejandro

Abstract excerpt

The melting temperature (Tm) of a protein is the temperature at which half of the protein population is in a folded state. Therefore, Tm is a measure of the thermostability of a protein. Increasing the Tm of a protein is a critical goal in biotechnology and biomedicine. However, predicting the change in melting temperature (dTm) due to mutations at a single residue is difficult because it depends on an intricate...

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Identifiers

PMID: 30192891
DOI: 10.1371/journal.pone.0203819
PMCID: PMC6128648

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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