Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Topics Community

Article

Proteome-wide Mendelian randomization and functional studies uncover therapeutic targets for polycystic ovarian syndrome.

American journal of human genetics - 5 Dec 2024

Ni Feida, Wang Feixia, Sun Jing, Tu Mixue, Chen Jianpeng, Shen Xiling, Ye Xiaohang, Chen Ruixue, Liu Yifeng, Sun Xiao, Chen Jianhua, Li Xue, Zhang Dan

Abstract excerpt

Polycystic ovarian syndrome (PCOS) is an endocrine syndrome that affects a large portion of women worldwide. This proteogenomic and functional study aimed to uncover candidate therapeutic targets for PCOS. We comprehensively investigated the causal association between circulating proteins and PCOS using two-sample Mendelian randomization analysis. Cis-protein quantitative trait loci were derived from six...

Topics

Polycystic Ovary Syndrome
Female
Mendelian Randomization Analysis
Humans
Genome-Wide Association Study
Mice
Animals
Proteome
Quantitative Trait Loci
Protein Interaction Maps

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genetic Predisposition to Disease

Disease Models, Animal

Polymorphism, Single Nucleotide

Source

Open in PubMed Open full text

Identifiers

PMID: 39541979
DOI: 10.1016/j.ajhg.2024.10.008
PMCID: PMC11639085

Genes

EGLN1
CCN2
CXCL11
FSHB
POSTN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Proteome-wide Mendelian randomization and functional studies uncover therapeutic targets for polycystic ovarian syndrome.PMID 39541979Read ↗

From proteome to pathogenesis: investigating polycystic ovary syndrome with Mendelian randomization analysis.Semantic proximity Read ↗

Integrative multi-omics analysis of druggable genes for therapeutic target identification in polycystic ovary syndrome.Semantic proximity Read ↗

Potential therapeutic targets for ovarian hyperstimulation syndrome revealed by proteome-wide mendelian randomization and colocalization analysisSemantic proximity Read ↗

Phenome-wide Mendelian randomization mapping the influence of the plasma proteome on complex diseases.Semantic proximity Read ↗

Integrative Multi-cohort Transcriptomics and Network Pharmacology Analysis Reveals Key Network Nodes and Potential Drug Clues in PCOS Granulosa CellsSemantic proximity Read ↗

Mendelian randomization analysis identified potential genes pleiotropically associated with polycystic ovary syndromeSemantic proximity Read ↗

Causal Genes and Immune-Epigenetic Mechanisms Underlying Polycystic Ovary Syndrome: A Multi-Omics Mendelian Randomization StudySemantic proximity Read ↗

The effects of plasma protein levels on the risk of endometriosis: A Mendelian randomization study.Semantic proximity Read ↗

Identification of the hub genes in polycystic ovary syndrome based on disease‐associated molecule networkSemantic proximity Read ↗

Phenome-wide Mendelian randomization mapping the influence of the plasma proteome on complex diseasesSemantic proximity Read ↗

Prioritization of potential drug targets in ovarian-related diseases: Mendelian randomization and colocalization analyses.Semantic proximity Read ↗

Integrative Multi-omics Analysis for Prioritization of Candidate Genes in Polycystic Ovary Syndrome.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.