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Article

Toll-like receptor 4 promotes α-synuclein clearance and survival of nigral dopaminergic neurons.

The American journal of pathology - 1 Aug 2011

Stefanova Nadia, Fellner Lisa, Reindl Markus, Masliah Eliezer, Poewe Werner, Wenning Gregor K

Abstract excerpt

Toll-like receptors (TLRs) mediate innate immunity, and their dysregulation may play a role in α-synucleinopathies, such as Parkinson's disease or multiple system atrophy (MSA). The aim of this study was to define the role of TLR4 in α-synuclein-linked neurodegeneration. Ablation of TLR4 in a transgenic mouse model of MSA with oligodendroglial α-synuclein overexpression augmented motor disability and enhanced...

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Source

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Identifiers

PMID: 21801874
DOI: 10.1016/j.ajpath.2011.04.013
PMCID: PMC3157205

Genes

TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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