Article
Molecular characterization of the pediatric preclinical testing panel.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Jul 2008
Neale Geoffrey, Su Xiaoping, Morton Christopher L, Phelps Doris, Gorlick Richard, Lock Richard B, Reynolds C Patrick, Maris John M, Friedman Henry S, Dome Jeffrey, Khoury Joseph, Triche Timothy J, Seeger Robert C, Gilbertson Richard, Khan Javed, Smith Malcolm A, Houghton Peter J
Abstract excerpt
PURPOSE: Identifying novel therapeutic agents for the treatment of childhood cancers requires preclinical models that recapitulate the molecular characteristics of their respective clinical histotypes. EXPERIMENTAL DESIGN AND RESULTS: Here, we have applied Affymetrix HG-U133Plus2 profiling to an expanded panel of models in the Pediatric Preclinical Testing Program. Profiling led to exclusion of two tumor lines...
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