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Article

Photoreceptor oxidative stress in hyperoxia-induced proliferative retinopathy accelerates rd8 degeneration.

PloS one - 1 Jan 2017

Lajko Michelle, Cardona Herminio J, Taylor Joann M, Farrow Kathryn N, Fawzi Amani A

Abstract excerpt

To investigate the impact of photoreceptor oxidative stress on photoreceptor degeneration in mice carrying the rd8 mutation (C57BL/6N). We compared the hyperoxia-induced proliferative retinopathy (HIPR) model in two mouse strains (C57BL/6J and C57BL/6N). Pups were exposed to 75% oxygen, starting at birth and continuing for 14 days (P14). Mice were euthanized at P14, or allowed to recover in room air for one day...

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Share to Hyperoxia
Share to Immunohistochemistry
Share to Mice, Inbred C57BL

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Neovascularization, Pathologic

Share to Oxidative Stress

Share to Photoreceptor Cells

Share to Reactive Oxygen Species

Share to Retinal Diseases

Source

Open in PubMed Open full text

Identifiers

PMID: 28671996
DOI: 10.1371/journal.pone.0180384
PMCID: PMC5495396

Genes

NOX4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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