Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

TRAF7 contributes to tumor progression by promoting ubiquitin-proteasome mediated degradation of P53 in hepatocellular carcinoma

13 Nov 2021

Abstract excerpt

It has been proved that TRAFs family proteins played malfunctioning roles in the development of human cancers. TRAF7 is the last one of TRAFs family proteins to be found, which was demonstrated to be involved in a serious of cancers development. In this study, we systematically investigated the molecular mechanisms of TRAF7 in facilitating hepatocellular carcinoma (HCC). We discovered that TRAF7 was overexpressed...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to Cell death mechanisms and regulation
Share to interferon and immune responses

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34775479
DOI: 10.1038/s41420-021-00749-w

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

TRAF7 contributes to tumor progression by promoting ubiquitin-proteasome mediated degradation of P53 in hepatocellular carcinomaPMID 34775479Read ↗

The Emerging Role of TRAF7 in Tumor Development.Semantic proximity Read ↗

TRAIP functions as an oncogene in hepatocellular carcinoma via Rb/EZH2/p21 signaling pathwaySemantic proximity Read ↗

Unlocking hepatocellular carcinoma aggression: STAMBPL1-mediated TRAF2 deubiquitination activates WNT/PI3K/NF-kb signaling pathwaySemantic proximity Read ↗

Downregulation of ubiquitin E3 ligase TNF receptor-associated factor 7 leads to stabilization of p53 in breast cancer.Semantic proximity Read ↗

TRAF6 regulates tumour metastasis through EMT and CSC phenotypes in head and neck squamous cell carcinoma.Semantic proximity Read ↗

Genetic Alterations of TRAF Proteins in Human CancersSemantic proximity Read ↗

The structure of TRAF7 coiled-coil trimer provides insight into its function in zebrafish embryonic development.Semantic proximity Read ↗

USP7 mediates TRAF4 deubiquitination to facilitate the malignant phenotype of ovarian cancer via the RSK4/PI3K/AKT axis.Semantic proximity Read ↗

Alterations of Krüppel-like Factor Signaling and Potential Targeted Therapy for Hepatocellular CarcinomaSemantic proximity Read ↗

The TRAF2-p62 axis promotes proliferation and survival of liver cancer by activating mTORC1 pathwaySemantic proximity Read ↗

USP8 regulates liver cancer progression via the inhibition of TRAF6-mediated signal for NF-κB activation and autophagy induction by TLR4Semantic proximity Read ↗

TRAF6 regulates the signaling pathway influencing colorectal cancer function through ubiquitination mechanismsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.