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Article

Druggable Genome-Wide Mendelian Randomization Identifies Therapeutic Targets and DNA Methylation-Mediated Regulation in Urological Malignancies.

Technology in cancer research & treatment - 1 Jan 2026

Li Taoen, Wei Qiang

Abstract excerpt

IntroductionUrological cancers, including prostate, renal, and bladder cancers, present significant challenges to human health, particularly for patients in advanced stages due to limited targeted therapy options, high drug resistance, and poor prognosis. This study seeks to systematically identify new therapeutic targets by integrating multi-omics data and elucidating their molecular mechanisms.MethodsOur...

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Topics

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Share to DNA Methylation
Share to Epigenesis, Genetic
Share to Gene Expression Regulation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mendelian Randomization Analysis

Share to Molecular Targeted Therapy

Share to Quantitative Trait Loci

Share to Transcriptome

Share to Urologic Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 42098041
DOI: 10.1177/15330338261449014
PMCID: PMC13167369

Genes

PROC
SIK2
CELSR1
BNIP2
GPR17
GPS1
GRB10
GSTM1
KAT5
KLC3
MMP24

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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