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Article

A Mutation-Specific Decision Model for Segmental Versus Total Abdominal Colectomy in Hereditary Nonpolyposis Colorectal Cancer.

Diseases of the colon and rectum - 1 Mar 2026

Leung Sabrina W, Rehman Nisha S, Alatout Mayar H, Etzioni David A, Samadder N Jewel, Chang Yu-Hui H, Mishra Nitin, Young-Fadok Tonia M, Brady Justin T

Abstract excerpt

BACKGROUND: Metachronous cancer risk varies by mismatch repair mutation in patients with hereditary nonpolyposis colorectal cancer. Total colectomy offers decreased risk of metachronous colorectal cancers but decreased quality of life compared with segmental colectomy. OBJECTIVE: Compare segmental versus total colectomy for colon cancer via a mutation-specific Markov decision model. DESIGN: Simulated survival and...

Topics

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Colectomy
Decision Support Techniques
DNA Mismatch Repair
Markov Chains
MutL Protein Homolog 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

MutS Homolog 2 Protein

Neoplasms, Second Primary

Quality-Adjusted Life Years

Source

Identifiers

PMID: 41358683
DOI: 10.1097/DCR.0000000000004042

Genes

MLH1
MSH2
MSH6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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