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Article

Conversion analysis for mutation detection in MLH1 and MSH2 in patients with colorectal cancer.

JAMA - 16 Feb 2005

Casey Graham, Lindor Noralane M, Papadopoulos Nickolas, Thibodeau Stephen N, Moskow John, Steelman Scott, Buzin Carolyn H, Sommer Steve S, Collins Christine E, Butz Malinda, Aronson Melyssa, Gallinger Steven, Barker Melissa A, Young Joanne P, Jass Jeremy R, Hopper John L, Diep Anh, Bapat Bharati, Salem Michael, Seminara Daniela, Haile Robert

Abstract excerpt

CONTEXT: The accurate identification and interpretation of germline mutations in mismatch repair genes in colorectal cancer cases is critical for clinical management. Current data suggest that mismatch repair mutations are highly heterogeneous and that many mutations are not detected when convent...

Read the complete abstract on PubMed

Topics

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Share to Adaptor Proteins, Signal Transducing
Share to Base Pair Mismatch

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Blotting, Southern

Share to Colorectal Neoplasms, Hereditary Nonpolyposis

Share to Gene Conversion

Share to Germ-Line Mutation

Share to MutL Protein Homolog 1

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Source

Open in PubMed Open full text

Identifiers

PMID: 15713769
DOI: 10.1001/jama.293.7.799
PMCID: PMC2933041

Genes

MLH1
MSH2
MSH6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-15713769-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

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