Article
Benefits of colonoscopic surveillance and prophylactic colectomy in patients with hereditary nonpolyposis colorectal cancer mutations.
Annals of internal medicine - 15 Nov 1998
Syngal S, Weeks J C, Schrag D, Garber J E, Kuntz K M
Abstract excerpt
BACKGROUND: Predisposition genetic testing is now possible for many hereditary cancer syndromes, including hereditary nonpolyposis colorectal cancer. The optimal management of the elevated risk for cancer in carriers of mutations for hereditary nonpolyposis colorectal cancer is unclear. OBJECTIVE...
Topics
- Adult
- Aged
- Anastomosis, Surgical
- Colectomy
- Colonoscopy
- Colorectal Neoplasms, Hereditary Nonpolyposis
- Decision Support Techniques
- Heterozygote
- Humans
- Ileum
- Life Expectancy
- Markov Chains
- Middle Aged
- Mutation
- Proctocolectomy, Restorative
- Quality-Adjusted Life Years
- Rectum
- Sensitivity and Specificity