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Article

Cost-effectiveness of population-wide genomic screening for Lynch Syndrome and polygenic risk scores to inform colorectal cancer screening.

Genetics in medicine : official journal of the American College of Medical Genetics - 1 Feb 2025

Jiang Shangqing, Guzauskas Gregory F, Garbett Shawn, Graves John A, Williams Marc S, Hao Jing, Zhu Jinyi, Jarvik Gail P, Carlson Josh J, Peterson Josh F, Veenstra David L

Abstract excerpt

PURPOSE: Genomic screening to identify individuals with Lynch Syndrome (LS) and those with a high polygenic risk score (PRS) promises to personalize colorectal cancer (CRC) screening. Understanding its clinical and economic impact is needed to inform screening guidelines and reimbursement policies. METHODS: We developed a Markov model to simulate individuals over a lifetime. We compared LS+PRS genomic screening...

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Identifiers

PMID: 39360752
DOI: 10.1016/j.gim.2024.101285
PMCID: PMC12805663

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