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Article

Hereditary nonpolyposis colorectal cancer: diagnostic strategies and their implications.

Evidence report/technology assessment - 1 May 2007

Bonis Peter A, Trikalinos Thomas A, Chung Mei, Chew Priscilla, Ip Stanley, DeVine Deirdre A, Lau Joseph

Abstract excerpt

OBJECTIVES: Hereditary Nonpolyposis Colorectal Cancer (HNPCC) has been defined clinically and genetically. The disorder has traditionally been recognized in kindreds with a clustering of related cancers in association with mutations in DNA mismatch repair genes. HNPCC is associated with a substantially increased risk for several forms of malignancy but particularly colorectal and endometrial cancer. There were...

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Topics

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Share to Colorectal Neoplasms, Hereditary Nonpolyposis
Share to DNA Mismatch Repair

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to PMS2 gene

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Source

Open in PubMed Open full text

Identifiers

PMID: 17764220
PMCID: PMC4781224

Genes

MLH1
MSH2
MSH6
PMS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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