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Article

Cost-effectiveness Analysis of Genotype-Specific Surveillance and Preventive Strategies for Gynecologic Cancers Among Women With Lynch Syndrome.

JAMA network open - 1 Sept 2021

Wright Jason D, Silver Elisabeth R, Tan Sarah Xinhui, Hur Chin, Kastrinos Fay

Abstract excerpt

Importance: With the expansion of multigene testing for cancer susceptibility, Lynch syndrome (LS) has become more readily identified among women. The condition is caused by germline pathogenic variants in DNA mismatch repair genes (ie, MLH1, MSH2, MSH6, and PMS2) and is associated with high but variable risks of endometrial and ovarian cancers based on genotype. However, current guidelines on preventive...

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Identifiers

PMID: 34499134
DOI: 10.1001/jamanetworkopen.2021.23616
PMCID: PMC8430458

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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