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Article

TP53/KRAS variant allele frequency ratio predicts advanced disease in mucin-producing cystic neoplasms of the pancreas.

American journal of clinical pathology - 22 Jan 2026

Lin Ming-Tseh, Afghani Elham, Canto Marcia I, Zhu Jing, Ali Syed Z, Wood Laura D, He Jin, Lafaro Kelly J, Hruban Ralph H, Eshleman James R

Abstract excerpt

OBJECTIVE: To identify molecular markers that predict advanced disease in mucin-producing cystic neoplasms of the pancreas. METHODS: In this single-institution study, 454 pancreatic cystic fluid specimens were examined by a clinical next-generation sequencing assay. RESULTS: TP53 mutations were detected in 25 (7.9%) of 318 specimens harboring KRAS (BRAF or GNAS) mutation(s). Of the 25, 12 had advanced...

Topics

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Aged
Aged, 80 and over
Biomarkers, Tumor
Gene Frequency
Mucins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Pancreatic Neoplasms

Proto-Oncogene Proteins p21(ras)

Tumor Suppressor Protein p53

Source

Open in PubMed Open full text

Identifiers

PMID: 41348949
DOI: 10.1093/ajcp/aqaf133
PMCID: PMC12854928

Genes

TP53
KRAS
BRAF
CDKN2A
GNAS
SMAD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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