Article
Analysis of error profiles of indels and structural variants in deep-sequencing data.
Cell genomics - 11 Feb 2026
Shao Ying, Tran Quang, Feng Yuan, Kolekar Pandurang, Liu Yanling, Liang Zhikai, Fan Li, McBride Andrea, Jones Tyler, Cameron Alexis, Mulder Heather, Ji Lingyun, Huang Benjamin J, Klco Jeffery M, Meshinchi Soheil, Zhang Jinghui, Carroll William L, Loh Mignon L, Easton John, Brown Patrick A, Ma Xiaotu
Abstract excerpt
Despite extensive studies of the error profiles of SNVs, those of insertions/deletions (indels)/structural variants (SVs) remain elusive. Using ultra-deep sequencing, we show that the error rates of indel/SVs are >100-fold lower than those of SNVs, although repeat indels have high error rates of 1%. We validated this pattern in a cohort of 103 patients with relapsed B cell acute lymphoblastic leukemia (B-ALL). We...
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