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Article

Herpesvirus tegument protein activates NF-kappaB signaling through the TRAF6 adaptor protein.

Proceedings of the National Academy of Sciences of the United States of America - 12 Aug 2008

Liu Xueqiao, Fitzgerald Katherine, Kurt-Jones Evelyn, Finberg Robert, Knipe David M

Abstract excerpt

Viruses remodel the host cell to optimize their replication both by delivery of virion proteins into the cell and by de novo expression of viral proteins. The HSV particle contains several proteins that function to prepare the host cell for viral replication, including the VP16 transcriptional activator protein and virion host shutoff protein. HSV infection activates NF-kappaB pathways through Toll-like receptor...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18682563
DOI: 10.1073/pnas.0801617105
PMCID: PMC2516262

Genes

TRAF6
TLR2
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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