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Comparative Analysis of <i>UL16</i> Mutants Derived from Multiple Strains of HSV-2 and HSV-1 Reveals Species-Specific Requirements for the UL16 Protein

2018-03-02

Abstract excerpt

Orthologs of the herpes simplex virus (HSV) UL16 gene are conserved throughout the Herpesviridae . Because of this conservation, one might expect that these proteins perform similar functions for all herpesviruses. Previous studies on a UL16 null mutant derived from HSV-2 strain 186 revealed a roughly 100-fold replication defect and a critical role for UL16 in the nuclear egress of capsids. These findings were...

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Literature Corpus work
f38e1a33-8c06-5121-ac3b-d06c69d6395f
DOI
10.1101/274548
Open publication

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Comparative Analysis of <i>UL16</i> Mutants Derived from Multiple Strains of HSV-2 and HSV-1 Reveals Species-Specific Requirements for the UL16 ProteinDOI 10.1101/274548
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