Article
A single intramuscular vaccination of mice with the HSV-1 VC2 virus with mutations in the glycoprotein K and the membrane protein UL20 confers full protection against lethal intravaginal challenge with virulent HSV-1 and HSV-2 strains.
PloS one - 1 Jan 2014
Stanfield Brent A, Stahl Jacque, Chouljenko Vladimir N, Subramanian Ramesh, Charles Anu-Susan, Saied Ahmad A, Walker Jason D, Kousoulas Konstantin G
Abstract excerpt
Herpes Simplex Virus type-1 (HSV-1) and type-2 (HSV-2) establish life-long infections and cause significant orofacial and genital infections in humans. HSV-1 is the leading cause of infectious blindness in the western world. Currently, there are no available vaccines to protect against herpes simplex infections. Recently, we showed that a single intramuscular immunization with an HSV-1(F) mutant virus lacking...
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