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Article

The pUL37 tegument protein guides alpha-herpesvirus retrograde axonal transport to promote neuroinvasion.

PLoS pathogens - 1 Dec 2017

Richards Alexsia L, Sollars Patricia J, Pitts Jared D, Stults Austin M, Heldwein Ekaterina E, Pickard Gary E, Smith Gregory A

Abstract excerpt

A hallmark property of the neurotropic alpha-herpesvirinae is the dissemination of infection to sensory and autonomic ganglia of the peripheral nervous system following an initial exposure at mucosal surfaces. The peripheral ganglia serve as the latent virus reservoir and the source of recurrent infections such as cold sores (herpes simplex virus type I) and shingles (varicella zoster virus). However, the means...

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Identifiers

PMID: 29216315
DOI: 10.1371/journal.ppat.1006741
PMCID: PMC5749899

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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