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Article

Single nucleotide polymorphisms of gemcitabine metabolic genes and pancreatic cancer survival and drug toxicity.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jan 2010

Okazaki Taro, Javle Milind, Tanaka Motofumi, Abbruzzese James L, Li Donghui

Abstract excerpt

PURPOSE: To show whether single nucleotide polymorphisms (SNP) of drug metabolic genes were associated with toxicity of 2',2'-difluoro 2'-deoxycytidine (gemcitabine)-based chemoradiotherapy and overall survival (OS) of patients with pancreatic cancer. EXPERIMENTAL DESIGN: We evaluated 17 SNPs of the CDA, dCK, DCTD, RRM1, hCNT1, hCNT2, hCNT3, and hENT1 genes in 154 patients with potentially resectable pancreatic...

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Source

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Identifiers

PMID: 20028759
DOI: 10.1158/1078-0432.CCR-09-1555
PMCID: PMC2802655

Genes

CDA
DCTD
RRM1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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