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HNF1A regulates oxaliplatin resistance in pancreatic cancer by targeting 53BP1

22 Feb 2023

Abstract excerpt

DNA double‑strand break repair is critically involved in oxaliplatin resistance in pancreatic ductal adenocarcinoma (PDAC). Hepatocyte nuclear factor 1 homeobox A (HNF1A) has received increased attention regarding its role in cancer progression. The present study explored the role of HNF1A in oxaliplatin resistance in PDAC. The results revealed that HNF1A expression was negatively associated with oxaliplatin...

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PMID: 36825600
DOI: 10.3892/ijo.2023.5493

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