Article
Nrf2 is overexpressed in pancreatic cancer: implications for cell proliferation and therapy.
Molecular cancer - 13 Apr 2011
Lister Adam, Nedjadi Taoufik, Kitteringham Neil R, Campbell Fiona, Costello Eithne, Lloyd Bryony, Copple Ian M, Williams Samantha, Owen Andrew, Neoptolemos John P, Goldring Chris E, Park B Kevin
Abstract excerpt
BACKGROUND: Nrf2 is a key transcriptional regulator of a battery of genes that facilitate phase II/III drug metabolism and defence against oxidative stress. Nrf2 is largely regulated by Keap1, which directs Nrf2 for proteasomal degradation. The Nrf2/Keap1 system is dysregulated in lung, head and neck, and breast cancers and this affects cellular proliferation and response to therapy. Here, we have investigated...
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