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Article

Pathway-Informed Machine Learning Identifies Genetic Predictors of High-Dose Methotrexate-Induced Mucositis in Pediatric Acute Lymphoblastic Leukemia.

Clinical pharmacology and therapeutics - 1 Feb 2026

Zhang Xiao Yu Cindy, Scott Erika N, Maagdenberg Hedy, Man Alice, Li Kathy H, Rassekh S Rod, Carleton Bruce C, Ross Colin J D, Wasserman Wyeth W, Loucks Catrina M

Abstract excerpt

High-dose methotrexate for pediatric cancer treatment is frequently associated with mucositis, which can lead to delayed or discontinued treatment and impact survival. While individual genetic variants have been implicated, the cumulative impact of genetic variation within relevant biological pathways remains unexplored. We evaluated single nucleotide polymorphisms across 18 pathways previously identified as...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41321063
DOI: 10.1002/cpt.70135
PMCID: PMC12816430

Genes

CAPN9
IL17B
IL6
MAST3
PRKCD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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