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Single-Cell View of Tumor Microenvironment Gradients in Pleural Mesothelioma

3 Jul 2024

Abstract excerpt

Immunotherapies have shown great promise in pleural mesothelioma (PM), yet most patients still do not achieve significant clinical response, highlighting the importance of improving the understanding of the tumor microenvironment (TME). Here, we utilized high-throughput, single-cell RNA sequencing (scRNA-seq) to de novo identify 54 expression programs and construct a comprehensive cellular catalog of the PM TME....

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PMID: 38959428
DOI: 10.1158/2159-8290.cd-23-0017

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