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Article

Polygenic Childhood Obesity: Integrating Genetics and Environment for Early Intervention.

Hormone research in paediatrics - 1 Jan 2026

van Uhm Jorrit, van Rossum Elisabeth F C, van Haelst Mieke M, Jansen Philip R, van den Akker Erica L T

Abstract excerpt

<p>Background: Childhood obesity is a global health challenge driven by a complex interplay of genetic predispositions and environmental exposures. Genome-wide association studies have identified many obesity-associated loci, and polygenic risk scores (PRS) enable quantification of genetic susceptibility. Concurrently, lifestyle factors - including diet, physical activity, sleep, stress, and socioeconomic status...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40527292
DOI: 10.1159/000546951
PMCID: PMC12266691

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