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Article

Characterization of the brain lipidome associated with frontotemporal lobar degeneration MAPT P301S mutation.

Journal of lipid research - 1 Jan 2026

Maroto-Juanes Almudena, Vogels Thomas, Koppes-den Hertog Sascha, Loos Maarten, Lütjohann Dieter, Giera Martin, van der Kant Rik

Abstract excerpt

Mutations in microtubule-associated protein Tau (MAPT), the gene that codes for the protein Tau, cause frontotemporal lobar degeneration (FTLD) with phenotypes ranging from behavioral changes to cognitive impairment and parkinsonism. Recently, lipid changes have been heavily implicated in synucleinopathies and secondary tauopathies such as Alzheimer's disease. Whether mutations in MAPT or accumulation of...

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Identifiers

PMID: 41318029
DOI: 10.1016/j.jlr.2025.100952
PMCID: PMC12796110

Genes

MAPT

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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