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Article

Human induced pluripotent stem cell-derived fiber-shaped cardiac tissue on a chip

1 Jan 2016

Abstract excerpt

We propose a method for the production of a fiber-shaped three-dimensional (3D) cellular construct of human induced pluripotent stem cell-derived cardiomyocytes (hiPS-CMs) for the quantification of the contractile force. By culturing the cardiomyocytes in a patterned hydrogel structure with fixed edges, we succeeded in fabricating hiPS-CM fibers with aligned cardiomyocytes. The fiber generated contractile force...

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PMID: 27217209
DOI: 10.1039/c6lc00422a

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