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Article

Causal association between circulating leukocyte characteristics and diabetic retinopathy based on two-sample Mendelian randomization.

Journal of diabetes investigation - 1 Feb 2026

Wang Yan, Gao Yunxian, Wang Zhiqiang, Wu Luhua, Guo Lixia, Zhang Xiaoqiang, Wu Jiaxin, Shang Shanshan

Abstract excerpt

AIMS/INTRODUCTION: Leukocytes are implicated in the inflammatory cascades of diabetic retinopathy (DR), but their causal roles remain ambiguous. This study employed a two-sample Mendelian randomization (MR) analysis to dissect the causal effects of circulating leukocyte counts on DR risk. MATERIALS AND METHODS: We utilized summary statistics from large-scale genome-wide association studies (GWAS) for five...

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Diabetic Retinopathy
Genetic Predisposition to Disease
Genome-Wide Association Study
Leukocyte Count
Leukocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mendelian Randomization Analysis

Polymorphism, Single Nucleotide

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Identifiers

PMID: 41311028
DOI: 10.1111/jdi.70196
PMCID: PMC12863003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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