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Article

Identification of common human TMEM173 genotypes associated with Alzheimer's disease.

Journal of Alzheimer's disease : JAD - 1 Jan 2026

Usher Mollie R, Aybar-Torres Alexandra A, Jin Lei

Abstract excerpt

BackgroundRecent animal studies have revealed STING (Stimulator of interferon genes) as a potential key player in Alzheimer's disease (AD). The actual impact of human STING on AD, however, is unknown. Mouse STING studies were done in WT/WT. However, TMEM173, the human gene encodes STING, has 5 common, distinct, sometimes opposite functional alleles that result in 25 TMEM173 genotypes. Only ∼50% of whites, 36% of...

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Identifiers

PMID: 41308015
DOI: 10.1177/13872877251396973
PMCID: PMC12765576

Genes

APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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