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Article

Proton pump inhibitors and the risk of urolithiasis: A Mendelian randomization study.

Medicine - 21 Nov 2025

Guo Jiawei, Chen Xinyu, Dou Yongqi, Xiong Yongjiang, Zhao Tao

Abstract excerpt

Observational studies suggest that proton pump inhibitors (PPIs) increase the risk of urolithiasis (UL). However, the causal correlation between the 2 is still unclear. To examine the causal relationship between PPIs and UL, this study used 2-sample Mendelian randomization. The genome-wide association studies (GWAS) of Omeprazole, Esomeprazole, Lansoprazole, and Rabeprazole medication can be obtained from GWAS...

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Identifiers

PMID: 41305821
DOI: 10.1097/MD.0000000000045646
PMCID: PMC12643632

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