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Article

Causal effects of obesity on urolithiasis and the mediating role of inflammatory factors: A two-sample Mendelian randomization study.

Medicine - 8 May 2026

Chen Jingan, Song Cheng, Chen Chongyang, You Mingpo, Chen Bin

Abstract excerpt

This study aimed to investigate the genetic causal relationship between obesity and urolithiasis using a two-sample Mendelian randomization (MR) approach. It further explored the potential mediating role of inflammatory factors in this causal pathway. Single nucleotide polymorphisms (SNPs) associated with body mass index, waist-to-hip ratio, and urolithiasis were obtained from publicly available genome-wide...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42116346
DOI: 10.1097/MD.0000000000048688
PMCID: PMC13166603

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