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Article

NOTCH1 mutation status as a prognostic biomarker in T-cell acute lymphoblastic leukemia: a systematic review and meta-analysis.

BMC cancer - 25 Nov 2025

Al Kuwari Hissa, Al Khinji Aisha, Al-Hamed Deema, Al Hor Abdullatif, Malouche Dhafer, Iqbal Javeed

Abstract excerpt

BACKGROUND: The prognostic significance of NOTCH1 mutations in T-cell acute lymphoblastic leukemia (T-ALL) remains uncertain. This study evaluates their impact on key clinical outcomes. METHODS: A systematic search of the Cochrane Library, PubMed, and CINAHL identified eleven peer-reviewed studies encompassing 2,039 patients. Data were independently extracted by two reviewers and analyzed using RevMan 5.4.1....

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41291497
DOI: 10.1186/s12885-025-15233-2
PMCID: PMC12648876

Genes

NOTCH1
EFS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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NOTCH1 mutation status as a prognostic biomarker in T-cell acute lymphoblastic leukemia: a systematic review and meta-analysis.PMID 41291497Read ↗

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