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Article

Emotional-Behavioral Dysregulation and Cortical Alterations in Pediatric Diffuse Midline Glioma With H3K27M Mutant: A Case-Control Study.

Neurosurgery - 1 Aug 2026

Mai Yiying, Jia Heyuan, Zhou Hang, Jiang Kai, Zhang Peng, Zhang Liwei

Abstract excerpt

BACKGROUND AND OBJECTIVES: Emotional-behavioral dysregulation (EBD) significantly affects the quality of life of glioma patients, but few studies report their psychopathological state and related cortical changes in children with diffuse midline gliomas (DMGs) with H3K27M mutant, hindering the implementation of interventions. We aim to explore the relationships among H3K27M mutation, EBD, and cortical remodeling....

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Identifiers

PMID: 41288362
DOI: 10.1227/neu.0000000000003860

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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