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Aspirin and hepatocellular carcinoma risk in metabolic dysfunction-associated steatotic liver disease: nationwide cohort study with genetic risk analysis.

Clinical and molecular hepatology - 1 Jan 2026

Ahn Juhee, Hur Moon Haeng, Shin Hyunjae, Park Min Kyung, Won Sungho, Park Jeayeon, Ko Yunmi, Park Youngsu, Lee Yun Bin, Cho Eun Ju, Lee Jeong-Hoon, Yu Su Jong, Yoon Jung-Hwan, Kim Yoon Jun

Abstract excerpt

BACKGROUND/AIMS: The association between aspirin use and hepatocellular carcinoma (HCC) risk in patients with metabolic dysfunction-associated steatotic liver disease (MASLD) remains unclear. This study evaluated the effect of aspirin on HCC development in MASLD patients using Korean National Health Insurance Service (NHIS) and UK Biobank (UKB) databases. METHODS: A retrospective cohort analysis was conducted...

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Identifiers

PMID: 41287437
DOI: 10.3350/cmh.2025.0528
PMCID: PMC12835774

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