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Article

Avian Influenza Virus A(H5N1) Genotype D1.1 Is Better Adapted to Human Nasal and Airway Organoids Than Genotype B3.13.

The Journal of infectious diseases - 17 Mar 2026

Zhang Xiaojuan, Lam Stephanie Joy-Ann, Chen Lin-Lei, Fong Carol Ho-Yan, Chan Wan-Mui, Ip Jonathan Daniel, Deng Shaofeng, Liu Siwen, Tam Rachel Chun-Yee, Wang Pui, Chan Kwok-Hung, Chan King-Pui Florence, Ho James Chung-Man, Zhou Jie, Yuen Kwok-Yung, Chen Honglin, To Kelvin Kai-Wang

Abstract excerpt

Three critically ill or fatal avian influenza A(H5N1) human infections have been reported in North America since November 2024. Notably, all were infected with genotype D1.1 instead of B3.13, the dominant genotype before November 2024. Here, we demonstrated that D1.1 could replicate to higher titers in human nasal and airway organoid-derived transwell monolayers from 6 donors. D1.1 exhibited a better binding to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41284739
DOI: 10.1093/infdis/jiaf598
PMCID: PMC13017197

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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