Tropism of influenza B viruses in human respiratory tract explants and airway organoids

Abstract excerpt

Despite causing regular seasonal epidemics with substantial morbidity, mortality and socioeconomic burden, there is still a lack of research into influenza B viruses (IBVs). In this study, we provide for the first time a systematic investigation on the tropism, replication kinetics and pathogenesis of IBVs in the human respiratory tract. Physiologically relevantex vivoexplant cultures of human bronchus and lung,...

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