γM23K mutation enhances ADP inhibition of mitochondrial F-ATPase yet has a minor effect on yeast growth rate.

Abstract excerpt

ADP inhibition of ATP hydrolysis is a conserved regulatory mechanism found in virtually all F-type ATP synthases. It occurs when ADP binds tightly to a catalytic site in the absence of phosphate, locking the enzyme in an inactive conformation. This inhibition is thought to prevent wasteful ATP hydrolysis, particularly under conditions where the proton-motive force is insufficient to drive ATP synthesis. However,...

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