Article
Deletion of mitochondrial ATPase inhibitor in the yeast Saccharomyces cerevisiae decreased cellular and mitochondrial ATP levels under non-nutritional conditions and induced a respiration-deficient cell-type.
Journal of biochemistry - 1 Dec 2001
Lu Y M, Miyazawa K, Yamaguchi K, Nowaki K, Iwatsuki H, Wakamatsu Y, Ichikawa N, Hashimoto T
Abstract excerpt
T(1), a mutant yeast lacking three regulatory proteins of F(1)F(o)ATPase, namely ATPase inhibitor, 9K protein and 15K protein, grew on non-fermentable carbon source at the same rate as normal cells but was less viable when incubated in water. During the incubation, the cellular ATP content decreased rapidly in the T(1) cells but not in normal cells, and respiration-deficient cells appeared among the T(1) cells....
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