Article
Slow Growth and Increased Spontaneous Mutation Frequency in Respiratory Deficient afo1- Yeast Suppressed by a Dominant Mutation in ATP3.
G3 (Bethesda, Md.) - 3 Dec 2020
Li Jing, Rinnerthaler Mark, Hartl Johannes, Weber Manuela, Karl Thomas, Breitenbach-Koller Hannelore, Mülleder Michael, Vowinckel Jakob, Marx Hans, Sauer Michael, Mattanovich Diethard, Ata Özge, De Sonakshi, Greslehner Gregor P, Geltinger Florian, Burhans Bill, Grant Chris, Doronina Victoria, Ralser Meryem, Streubel Maria Karolin, Grabner Christian, Jarolim Stefanie, Moßhammer Claudia, Gourlay Campbell W, Hasek Jiri, Cullen Paul J, Liti Gianni, Ralser Markus, Breitenbach Michael
Abstract excerpt
A yeast deletion mutation in the nuclear-encoded gene, AFO1, which codes for a mitochondrial ribosomal protein, led to slow growth on glucose, the inability to grow on glycerol or ethanol, and loss of mitochondrial DNA and respiration. We noticed that afo1- yeast readily obtains secondary mutations that suppress aspects of this phenotype, including its growth defect. We characterized and identified a dominant...
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