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Article

Longitudinal Genomic Analysis of Five Cases of Recurrent Thymomas.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 Apr 2026

He Yongfeng, Waltman Peter, Kane Troy, Sigouros Michael, Chandra Pooja, Gorski Kathryn, Zhang Chen, Proietti Agnese, Singh Arshdeep, Mittal Vivek, Altorki Nasser K, Elemento Olivier, Saxena Ashish, Alonso Alicia, Sboner Andrea, Petrini Iacopo, Giaccone Giuseppe

Abstract excerpt

INTRODUCTION: Genomic landscape of primary thymic epithelial tumors has been explored previously. However, the molecular alterations contributing to recurrence and potential transformation remain largely unknown. METHODS: We performed whole-exome sequencing on three primary and 11 recurrent thymoma samples from five patients using the novel EXaCT-2 platform. Genomic alterations, including somatic mutations and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 41274415
DOI: 10.1016/j.jtho.2025.11.011

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GTF2I

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