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Article

Computational Hydropathy Analysis of BamA Bacterial Outer Membrane Protein and Its Mutants.

The journal of physical chemistry. B - 4 Dec 2025

Farquhar Connor, Hightower Greta L, Forlenza Jackson T, Nangia Shivangi

Abstract excerpt

Outer Membrane Proteins (OMPs) are essential to the physiology of Gram-negative bacteria and are attractive targets for antimicrobial therapies. Their folding and insertion into the outer membrane are orchestrated by the β-barrel assembly machinery (BAM) complex, with BamA, its central and evolutionarily conserved component, playing a crucial role. BamA comprises five periplasmic polypeptide-transport-associated...

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PMID: 41270239
DOI: 10.1021/acs.jpcb.5c06046

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