Article
Lateral opening and exit pore formation are required for BamA function.
Structure (London, England : 1993) - 8 Jul 2014
Noinaj Nicholas, Kuszak Adam J, Balusek Curtis, Gumbart James C, Buchanan Susan K
Abstract excerpt
The outer membrane of Gram-negative bacteria is replete with a host of β-barrel outer membrane proteins (OMPs). Despite serving a variety of essential functions, including immune response evasion, the exact mechanism of OMP folding and membrane insertion remains largely unclear. The β-barrel assembly machinery complex is required for OMP biogenesis. Crystal structures and molecular dynamics (MD) simulations of...
Topics
- Bacterial Outer Membrane Proteins
- Cross-Linking Reagents
- Disulfides
- Escherichia coli
- Escherichia coli Proteins
- Molecular Dynamics Simulation
- Mutation
- Phosphines
- Protein Folding
- Protein Structure, Tertiary