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Article

Plasticity within the barrel domain of BamA mediates a hybrid-barrel mechanism by BAM.

Nature communications - 8 Dec 2021

Wu Runrun, Bakelar Jeremy W, Lundquist Karl, Zhang Zijian, Kuo Katie M, Ryoo David, Pang Yui Tik, Sun Chen, White Tommi, Klose Thomas, Jiang Wen, Gumbart James C, Noinaj Nicholas

Abstract excerpt

In Gram-negative bacteria, the biogenesis of β-barrel outer membrane proteins is mediated by the β-barrel assembly machinery (BAM). The mechanism employed by BAM is complex and so far- incompletely understood. Here, we report the structures of BAM in nanodiscs, prepared using polar lipids and native membranes, where we observe an outward-open state. Mutations in the barrel domain of BamA reveal that plasticity in...

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Identifiers

PMID: 34880256
DOI: 10.1038/s41467-021-27449-4
PMCID: PMC8655018

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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