Genetic and molecular mechanisms of hereditary thoracic aortic aneurysm and dissection (Review).

Abstract excerpt

Thoracic aortic aneurysm and dissection (TAAD) is a life‑threatening disease with an insidious onset and a largely elusive pathogenesis. Hereditary TAAD (HTAD) can be classified into syndromic forms, including Marfan syndrome, Loeys‑Dietz syndrome and vascular Ehlers‑Danlos syndrome and non‑syndromic forms, including familial TAAD and bicuspid aortic valve‑associated TAAD. Current evidence suggests that HTAD...

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