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Article

Interaction of Alzheimer's Disease-Associated Genetic Risk with Indicators of Socioeconomic Position on Mild Cognitive Impairment in the Heinz Nixdorf Recall Study.

Journal of Alzheimer's disease : JAD - 1 Jan 2021

Frank Mirjam, Hensel Jonas, Baak Lisa, Schramm Sara, Dragano Nico, Weimar Christian, Hoffmann Per, Nöthen Markus M, Erbel Raimund, Jöckel Karl-Heinz, Jokisch Martha, Schmidt Börge

Abstract excerpt

BACKGROUND: The apolipoprotein E (APOE) ɛ4 allele is reported to be a strong genetic risk factor for mild cognitive impairment (MCI) and Alzheimer's disease (AD). Additional genetic loci have been detected that influence the risk for late-onset AD. As socioeconomic position (SEP) is also strongly related to cognitive decline, SEP has been suggested to be a possible modifier of the genetic effect on MCI....

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PMID: 34219719
DOI: 10.3233/JAD-210244
PMCID: PMC8461721

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