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Article

MIF functional polymorphisms are associated with acute GVHD progression and steroid-refractoriness.

Frontiers in immunology - 1 Jan 2025

Aharon Aviran, Avni Batia, Louzoun Daniel, Elias Shlomo, Stepensky Polina, Ram Ron, Zuckerman Tsila, Meza-Romero Roberto, Vandenbark Arthur A, Grisariu Sigal, Benedek Gil

Abstract excerpt

Introduction: Approximately 50% of allogeneic hematopoietic stem cell transplantation (HSCT) Q6 recipients develop graft versus host disease (GVHD). Glucocorticoids (GC) are the first line of treatment for both acute and chronic GVHD. Failure to respond to GC [steroid-refractory (SR)] encompasses a very poor outcome with high mortality. Macrophage migration inhibitory factor (MIF) is released during...

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Source

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Identifiers

PMID: 40421032
DOI: 10.3389/fimmu.2025.1504976
PMCID: PMC12105047

Genes

MIF
GC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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