Article
Shared genetic architecture between autism spectrum disorder, loneliness, and social isolation reveals novel genetic loci.
Psychiatric genetics - 1 Mar 2026
Hope Sigrun, Lin Aihua, Rodevand Linn, Hübenette Saira Jameela, Quintana Daniel S, Sønderby Ida E, Cheng Weiqiu, Frei Oleksandr, Bahrami Shahram, Hindley Guy F L, Kaale Anett, Shadrin Alexey A, O'Connell Kevin S, Parker Nadine, Djurovic Srdjan, Nærland Terje, Andreassen Ole A
Abstract excerpt
OBJECTIVE: Deficits in social communication and social interaction are core features of autism spectrum disorder (ASD), and studies suggest that loneliness and social isolation are common. ASD has a strong genetic basis, but the genetic architecture and overlap with social phenotypes are not clear. METHODS: We analyzed summary statistics from genome-wide association studies on ASD (46 350), loneliness (452 302),...
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