Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Polygenic overlap and shared genetic loci between loneliness, severe mental disorders, and cardiovascular disease risk factors suggest shared molecular mechanisms.

Translational psychiatry - 5 Jan 2021

Rødevand Linn, Bahrami Shahram, Frei Oleksandr, Lin Aihua, Gani Osman, Shadrin Alexey, Smeland Olav B, Connell Kevin S O', Elvsåshagen Torbjørn, Winterton Adriano, Quintana Daniel S, Hindley Guy F L, Werner Maren C F, Djurovic Srdjan, Dale Anders M, Lagerberg Trine V, Steen Nils Eiel, Andreassen Ole A

Abstract excerpt

Clinical and epidemiological evidence suggest that loneliness is associated with severe mental disorders (SMDs) and increases the risk of cardiovascular disease (CVD). However, the mechanisms underlying the relationship between loneliness, SMDs, and CVD risk factors remain unknown. Here we explored overlapping genetic architecture and genetic loci shared between SMDs, loneliness, and CVD risk factors. We analyzed...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cardiovascular Diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Loci

Share to Genetic Predisposition to Disease

Share to Genome-Wide Association Study

Share to Polymorphism, Single Nucleotide

Share to Risk Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 33414458
DOI: 10.1038/s41398-020-01142-4
PMCID: PMC7790035

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Polygenic overlap and shared genetic loci between loneliness, severe mental disorders, and cardiovascular disease risk factors suggest shared molecular mechanisms.PMID 33414458Read ↗

Phenome-wide Investigation of Health Outcomes Associated with Genetic Predisposition to LonelinessSemantic proximity Read ↗

Genetic risk for major depressive disorder and loneliness in sex-specific associations with coronary artery disease.Semantic proximity Read ↗

Unraveling the heart-brain axis: shared genetic mechanisms in cardiovascular diseases and SchizophreniaSemantic proximity Read ↗

Understanding the relationship between loneliness, substance use traits and psychiatric disorders: A genetically informed approach.Semantic proximity Read ↗

Shared genetic architecture between autism spectrum disorder, loneliness, and social isolation reveals novel genetic loci.Semantic proximity Read ↗

Polygenic contribution to the relationship of loneliness and social isolation with schizophrenia.Semantic proximity Read ↗

Genetic risk for major depressive disorder and loneliness in gender-specific associations with coronary artery diseaseSemantic proximity Read ↗

Examining the genetic relationship between Alzheimer’s disease, schizophrenia and their shared risk factors using genomic structural equation modellingSemantic proximity Read ↗

Linking prolonged childhood and adolescent loneliness to schizophrenia spectrum disorders: results from EU-GEI study.Semantic proximity Read ↗

Characterizing the Shared Genetic Underpinnings of Schizophrenia and Cardiovascular Disease Risk Factors.Semantic proximity Read ↗

Evidence for Shared Genetic Aetiology Between Schizophrenia, Cardiometabolic, and Inflammation-Related Traits: Genetic Correlation and Colocalization AnalysesSemantic proximity Read ↗

Evidence for overlapping genetic architecture between lifestyle factors and severe mental disorders with different patterns across diagnoses.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.